Selected Publications

Modelling Aqueous Solubility. Butina, Darko; Gola, Joelle; J. Chem. Inf. Comput. Sci. (2003)

Predicting ADME properties in silico: methods and models. Butina, Darko; Segall, Matthew; Frankcombe, Katrina; DDT (2002), 7(11) S83-S88.

A rapid and facile method for the dereplication of purified natural products. Sidebottom P J.; Butina D.; Bradshaw J et al., J. Nat. Prod. (2001), 64(12) 1541-4.

Correlation and prediction of large blood-brain distribution data set – an LFER study. Platts, James A.; Abraham, Michael H.; Hersey, Anne; Butina, Darko et al., Eur. J. Med. Chem. (2001), 36(9) 719-30.

Evaluation of human intestinal absorption data and subsequent derivation of QSAR with Abraham descriptors. Platts, James A.; Abraham, Michael H.; Hersey, Anne; Butina, Darko et al., J. Pharm. Res. (2001), 90(6) 749-84.

Estimation of molecular linear free energy relationship descriptors. 4. Correlation and prediction of cell permeation. Platts, James A.; Abraham, Michael H.; Hersey, Anne; Butina, Darko. Department of Chemistry, University College London, London, UK. Pharm. Res. (2000), 17(8), 1013-1018. CODEN: PHREEB ISSN: 0724-8741. Journal written in English. AN 2000:700682 CAPLUS

Estimation of Molecular Linear Free Energy Relationship Descriptors by a Group Contribution Approach. 2. Prediction of Partition Coefficients. Platts, James A.; Abraham, Michael H.; Butina, Darko; Hersey, Anne. Department of Chemistry, University College London, London, UK. J. Chem. Inf. Comput. Sci. (2000), 40(1), 71-80. CODEN: JCISD8 ISSN: 0095-2338. Journal written in English. CAN 132:78160 AN 1999:757513 CAPLUS

Estimation of molecular linear free energy relation descriptors using a group contribution approach. Platts, James A.; Butina, Darko; Abraham, Michael H.; Hersey, Anne. Department of Chemistry, University College London, London, UK. J. Chem. Inf. Comput. Sci. (1999), 39(5), 835-845. CODEN: JCISD8 ISSN: 0095-2338. Journal written in English. CAN 131:199284 AN 1999:455142 CAPLUS

Unsupervised data base clustering based on Daylight's fingerprint and Tanimoto similarity: a fast and automated way to cluster small and large data sets. Butina, Darko. Science Development Group - Biomet, Glaxo Wellcome Research and Development Medicines Research Centre, Stevenage Hertfordshire, UK. J. Chem. Inf. Comput. Sci. (1999), 39(4), 747-750. CODEN: JCISD8 ISSN: 0095-2338. Journal written in English. CAN 131:256996 AN 1999:401262 CAPLUS

Preparation and formulation of 3-(4-piperidinyl)indole-5-ethanesulfonamides for treatment of headache. Oxford, Alexander William; Butina, Darko; Owen, Martin Richard. (Glaxo Group Ltd., UK). Eur. Pat. Appl. (1989), 21 pp. CODEN: EPXXDW EP 303507 A2 19890215 Designated States R: AT, BE, CH, DE, ES, FR, GB, GR, IT, LI, LU, NL, SE. Patent written in English. Application: EP 88-307499 19880812. Priority: GB 87-19167 19870813; GB 88-14002 19880614; GB 88-14481 19880617. CAN 111:57535 AN 1989:457535 CAPLUS

Preparation of 3-(4-piperidinyl)- and 3-(1,2,3,6-tetrahydro-4-pyridinyl)indoles as antimigraine agents. Oxford, Alexander William; Coates, Ian Harold; Butina, Darko. (Glaxo Group Ltd., UK). Eur. Pat. Appl. (1989), 18 pp. CODEN: EPXXDW EP 303506 A2 19890215 Designated States R: AT, BE, CH, DE, ES, FR, GB, GR, IT, LI, LU, NL, SE. Patent written in English. Application: EP 88-307498 19880812. Priority: GB 87-19167 19870813. CAN 111:23389 AN 1989:423389 CAPLUS

GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein. Humphrey, P. P. A.; Feniuk, W.; Perren, M. J.; Connor, H. E.; Oxford, A. W.; Coates, I. H.; Butina, D.. Glaxo Group Res. Ltd., Ware/Hertfordshire, UK. Br. J. Pharmacol. (1988), 94(4), 1123-32. CODEN: BJPCBM ISSN: 0007-1188. Journal written in English. CAN 109:122931 AN 1988:522931 CAPLUS

Preparation and formulation of indolesulfonamides useful in treatment of migraine. Butina, Darko; Webb, Colin Frederick; Dowle, Michael Dennis; Bays, David Edmund. (Glaxo Group Ltd., UK). Eur. Pat. Appl. (1988), 18 pp. CODEN: EPXXDW EP 254433 A2 19880127 Designated States R: AT, BE, CH, DE, ES, FR, GB, IT, LI, NL, SE. Patent written in English. Application: EP 87-305707 19870626. Priority: GB 86-15599 19860626. CAN 109:6410 AN 1988:406410 CAPLUS

Indole derivatives and pharmaceutical compositions containing them. Evans, Brian; Oxford, Alexander William; Butina, Darko. (Glaxo Group Ltd., UK). Ger. Offen. (1986), 56 pp. CODEN: GWXXBX DE 3542698 A1 19860605 Patent written in German. Application: DE 85-3542698 19851203. Priority: GB 84-30624 19841204; GB 84-30625 19841204; GB 84-30626 19841204; GB 84-30773 19841205. CAN 105:152923 AN 1986:552923 CAPLUS

Indole derivatives, pharmaceutical compositions containing them, and their medical use in the treatment of migraine. Butina, Darko; Dowle, Michael Dennis; Coates, Ian Harold. (Glaxo Group Ltd., UK). Eur. Pat. Appl. (1985), 46 pp. CODEN: EPXXDW EP 147107 A1 19850703 Designated States R: BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. Patent written in English. Application: EP 84-308493 19841206. Priority: GB 83-32437 19831206. CAN 104:148733 AN 1986:148733 CAPLUS

Indolylmethylsulfonamides. Butina, Darko. (Glaxo Group Ltd., UK). Eur. Pat. Appl. (1985), 22 pp. CODEN: EPXXDW EP 145459 A2 19850619 Designated States R: AT, BE, CH, DE, FR, GB, IT, LI, NL, SE. Patent written in English. Application: EP 84-308492 19841206. Priority: GB 83-32434 19831206. CAN 103:215165 AN 1985:615165 CAPLUS

The synthesis of g-fluoroisoleucine. Butina, D.; Hudlicky, M. Dep. Chem., Virginia Polytech. Inst. State Univ., Blacksburg, VA, USA. J. Fluorine Chem. (1980), 16(4), 301-23. CODEN: JFLCAR ISSN: 0022-1139. Journal written in English. CAN 94:157207 AN 1981:157207 CAPLUS

Syntheses of 1-cyclopentene-1,2-dicarboxaldehyde and 1-cyclobutene-1,2-dicarboxaldehyde. Butina, Darko; Sondheimer, Franz. Chem. Dep., Univ. Coll. London, London, Engl. Synthesis (1980), (7), 543-5. CODEN: SYNTBF ISSN: 0039-7881. Journal written in English. CAN 94:15237 AN 1981:15237 CAPLUS

Stereospecific synthesis of a-amino-b-hydroxy acids. Shanzer, Abraham; Somekh, Lila; Butina, Darco. Dep. Org. Chem., Weizmann Inst. Sci., Rehovot, Israel. J. Org. Chem. (1979), 44(22), 3967-9. CODEN: JOCEAH ISSN: 0022-3263. Journal written in English. CAN 91:193600 AN 1979:593600 CAPLUS